In a couple of months, Roger Y. Tsien and Martin Chalfie will head to Stockholm to collect the Nobel Prize in Chemistry and $450,000 each in prize money in recognition of their development of a revolutionary technique that lights up the inner workings of living cells.
Meanwhile, the scientist who provided the essential piece that made Dr. Tsien’s and Dr. Chalfie’s work possible — a jellyfish gene that produces a fluorescent protein — is out of science.
Douglas C. Prasher, who conducted his research on the Aequorea victoria jellyfish while at the Woods Hole Oceanographic Institution in Massachusetts in the early 1990s, now drives a courtesy van for a car dealer in Huntsville, Ala., earning $10 an hour. He said he was not bitter or jealous of this year’s winning chemistry Nobelists: Dr. Tsien of the University of California, San Diego, Dr. Chalfie of Columbia and Osamu Shimomura, the original discoverer of the jellyfish protein in 1961.
Trained as a biochemist, Dr. Prasher, 57, was interested in the chemistry of how certain animals are able to glow. In the late 1980s, he applied to the National Institutes of Health for a five-year grant to track down the fluorescent protein gene.
Dr. Prasher said his proposal included speculation on how the fluorescent protein might be used as a beacon to light up structures in cells. “That would have certainly been part of my research program,” Dr. Prasher said. “I knew it could serve as a genetic marker and it would be really, really useful, which it has turned out to be.”
That application was turned down. A parallel proposal to the American Cancer Society succeeded, giving Dr. Prasher only two years of financing, enough time to isolate the gene, but not pursue any applications.
By then, however, Dr. Prasher had decided that Woods Hole was not the place for him. Instead of going through the tenure process — he thought he would be turned down, anyway — he looked for a new job. Dr. Chalfie and Dr. Tsien independently contacted Dr. Prasher asking about the jellyfish gene. Dr. Prasher generously shared the gene with both of them.
Dr. Prasher then worked for the United States Department of Agriculture, first on Cape Cod and later in Beltsville, Md., developing methods for identifying pests and other insects. Again, he was not happy, experiencing the beginning of bouts of depression. “I was not happy with management there, so I looked for another position,” he said.
His next move was to Huntsville, where he worked for a NASA subcontractor that was developing mini-chemistry laboratories, which would be needed as health diagnostic tools for a potential human flight to Mars. Dr. Prasher loved that job, but NASA eliminated the financing for the project. For family reasons, he stayed in Huntsville, which restricted his opportunities. “The amount of life science done here is very limited,” he said.
The depression returned. “That’s been a serious problem off and on, but anyone who doesn’t have a job has that problem,” Dr. Prasher said. “If they don’t, there’s a problem with them. Or they’re independently wealthy.”
After a year of unemployment, he started driving the van for Bill Penney Toyota, his job for the last year and a half.
The above was snagged from Hullabaloo, but the entire NY Times article is here.
I'll be curious to see of The Huntsville Times has anything on Dr. Prasher's situation!
